THIS IS A BIG COSTLY PROBLEM

MACRO-MARKET FUNDAMENTALS DRIVING DEMAND

620M

Global population living with heart and circulatory diseases (British Heart Foundation 2023)

>30%

% of Americans defined as clinically obese (CDC 2022)

20.5M

Global deaths attributable to heart and circulatory diseases (British Heart Foundation 2023)

$2.4B

Annual heart attack wrongful death exposure (NEWMAN ET AL. 2022) (1.5% misdiagnosis rate, 40% malpractice win rate, $400k avg. indemnity payment)

27.5%

Annual U.S. missed/delayed MI detection rate (Newman et al. 2022)

CURRENT ECG Systemic problems & errors

CHALLENGES WITH CURRENT STANDARD-OF-CARE

User Error/Complexity

- 2 cm misplacement can hide a heart attack (false negatives) (Bond et al. 2012)

- 72% of unnecessary cath lab activations linked to ECG misinterpretation (false positives) (Degheim et al. 2019)

Time Consuming /Burdensome

- Each 1 min delay increases mortality 2% (Zuworska-Wolak et al. 2019)

- 29% of suspected STEMI patients did not receive ECG within 10 minutes (Stopyra et al. 2023)

User Error/Complexity

- Unreliable signal during transport.

- Poor tolerance to motion

- 28% transmission rates during acute MI (Bosson et al.)

- Serial ECGs significantly enhance STEMI detection (Verbeek et al. 2012)

Time Consuming /Burdensome

- Incompatible during CPR.

- Poor adhesion.

Hence, the EXG was born

Current AI algorithms have utilized a trove of ECG data collected over many years, most of which were done wrong

CITATIONS

(Cadet JV.) Report: cost savings will drive ECG global market to nearly $160M by 2015. Cardiovascular Business. 2009.

(Gregory et al.) Accuracy of ECG chest electrode placements by paramedics: an observational study. Briish Paramedic Journal. 2021, vol. 6(1) 8–14

(Bond et al.) / European Journal of Internal Medicine (2012) 23, 610-615. (Placement of leads leads to misinterpretation)

(Zuworska-Wolak et al.) / Scandinavian Journal of Trauma Resuscitation and Emergency Medicine (2019) 27:39. (Time each 1 min inc to Cath lab lead to inc mort 2%)

(Degheim et al.) False activation of the cardiac catheterization laboratory: the price to pay for shorter treatment delay. JRSM Cardiovascular Disease. Jan-Dec 2019, 8: 2048004019836365.

(Stopyra et al.) Prehospital time disparities for Rural Patients with Suspected STEMI. Prehospital Emergency Care 2023 (27) : 488-495

(Bosson et al.) / Prehospital Emergency Care, 19:4, 496-503. (28% transmission rate)

(Verbeek et al.) Serial prehospital 12-lead electrocardiograms increase identification of ST-segment elevation myocardial infarction. Prehospital emergency care. 16:1 109-14. 2012.

(Newman-Toker et al.) Diagnostic Errors in the Emergency Department: A Systematic Review. Comparative Effectiveness Review Number 258 2022.